Redox regulation of tumor suppressor PTEN in cell signaling
Hydration Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) is a potent tumor suppressor and often dysregulated in cancers.Cellular PTEN activity is restrained by the oxidation of active-site cysteine by reactive oxygen species (ROS).Recovery of its enzymatic activity predominantly depends on the availability of cellular thioredoxin (